Development Trend of Molecular Diagnostic Technology

Countries around the world attach great importance to the development of molecular diagnostic technology, and gene chips will become the mainstream of the development of new-generation molecular diagnostic reagents. Gene chip is the crystallization of the combination of molecular biology, microelectronics, computer and other disciplines.

The gene chip has the function of being able to detect multiple targets at the same time, which is fast and effective. Therefore, the gene chip has become the main development direction of a new generation of molecular diagnostic reagents, but its cost is high, the development is difficult, and there are few product types, which are only used for scientific research and drug screening.

The large-scale clinical application of gene chips still has technical deficiencies that have not yet been overcome, mainly due to the low specificity and sensitivity of chip diagnosis, the high cost of chip diagnosis, and the high price of supporting instruments for chip diagnosis. Globally, although only a few chips can be used for clinical diagnosis, domestic gene chip technology is already in a leading position in the world.

Gene chip technology will be the most challenging potential opponent of fluorescent quantitative PCR detection technology, mainly: fluorescent quantitative PCR technology can only detect one or several target genes at a time, while gene chip technology can detect a large number of target genes simultaneously.

With the progress of the Human Genome Project, gene chips have become a research hotspot at home and abroad. If the gene chip technology matures rapidly and is industrialized on a large scale, it will have a great impact on the detection of real-time quantitative PCR. However, the large-scale clinical application of gene chips still has technical defects that have not yet been overcome, mainly due to the low specificity and sensitivity of chip diagnosis, the high cost of chip diagnosis, and the high price of supporting instruments for chip diagnosis. Stay ahead for 5 to 10 years.